Table 4: Short-term effects of ozone on lung function, biological and other responses
| Reference |
Population |
Exposure |
Results |
Broeckaert et al 2000
(222) |
Cyclists |
In quartiles mean
48,72, 89 and 96
ppb |
Significant elevations
in CC-16 protein measured in Clara cells
for those exposed to 3rd and 4th quartile |
Holz et al
2002 (224) |
Allergic asthmatics |
|
Enhanced functional
and inflamatory bronchial response to inhaled
allergen challenge |
Frampton et al 1995
(214) |
Healthy and allergic
asthmatic nonsmokers |
3 hours to 80, 120
and 160 ppb after exposure to H2SO4
and NaCl |
Small, significant
reductions in FVC, FEV in the highest exposure
group, greater for those exposed to H2SO4
and bigger for asthmatics |
Frank et al
2001 (223) |
Young adults |
0.25 ppm for 2h over
4 days |
Spirometric values
show adaptation, persistent small airway
dysfunction/resistance |
Devlin et al
1997 (215) |
Young male adults |
Repetitive exposures
0.4ppm for 2h over 5 days |
Inflammatory mediators
are attenuated, some do not return to normal
after 20 days upon O3 challenge.
Several markers of cell injury are not attenuated |
Source: WHO Regional Office for Europe 
"Health Aspects of Air Pollution" (2003)
Chapter 6, Ozone (O3) Section 6.2 Answer and rationales, Question 12
(For numbered references see pages 58-88)
Related publication:
Other Figures & Tables on this publication:
Table 2. Summary of meta-analysis of time-series studies published during the period 1996–2001
Table 3: Summary of studies measuring short-term effect on lung function
Table 4: Short-term effects of ozone on lung function, biological and other responses
Figures: Examples of funnel plots and tests for publication bias
Table 1. Summary estimates for studies of PM10 and daily mortality by GAM or non-GAM statistical model and by single-city or multicity study design.
